Your sound design and composition here is spot-on for a spacey sci-fi story. The main thing that I think it could benefit from is more spacial mixing. I'd say the higher lead synths could do with some reverb, and maybe a subtle layer of broadband noise would help smooth out the mix. The high-resonance filter (0:40-2:15) and the fast arpeggio (0:30-1:20) are the two things that I found myself getting bothered by, and they were distracting from the other interesting sounds. It seems like there are a lot of sounds occupying the same frequency range in the first half, so there's a lot that's barely audible.
I love the bass synth, but between 2:00 and 2:30 sounds like it's bleeding through the filter somehow and letting unpleasant mid frequencies through, which sounds kind of like some sort of AC power interference.